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5-MeO-DMT or O-methyl-bufotenin is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and at least one toad species, the Sonoran Desert toad. Like its close relatives DMT and bufotenin, it has been used as an entheogen in South America

In a recent European study, after one single use, the substance 5-MeO-DMT was shown to produce sustained enhancement of satisfaction with life, and easing of anxiety, depression and post-traumatic stress disorder (PTSD).

When former heavyweight boxing champion Mike Tyson first tried 5-MeO-DMT — also called “the toad” — he said it knocked him off his feet, profoundly changing his life. “I came across this thing called the toad. I smoked this medicine, drug, whatever you want to call it, and I’ve never been the same,” Tyson said on the Joe Rogan Experience podcast last year, viewed by nearly 10 million people. “I look at life differently, I look at people differently. It’s almost like dying and being reborn… It’s inconceivable. I tried to explain it to some people, to my wife, I don’t have the words to explain it. It’s almost like you’re dying, you’re submissive, you’re humble, you’re vulnerable — but you’re invincible still in all.”

One single 50mg vaporized dose — derived from dried venom secreted by the Bufo alvarius toad — often produces hallucinogenic, boundless experiences within one second of inhalation that can last from 7 to 90 minutes, and on average lasts 20 minutes. Like Tyson, people report mystical experiences, many “seeing God,” and often sensing a better understanding of their place and function in the cosmos as a result. Shortly after use, participants tend to be totally clearheaded and 100% back to their previous ordinary state.


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