letrozole CAS NO: 112809-51-5

letrozole
CAS NO: 112809-51-5
Systematic (IUPAC) name: 4,4'-(1,2,4-triazol-1-ylmethyl)dibenzonitrile
Trade names: Femara
MF:C17H11N5
MW:285.3
Content: 99%
Molecular Formula: C17H11N5
Mol. mass: 285.303 g/mol
Quality standard: USP29
Apperance: white or off-white crystalline powder
Packing: 1kg/tin
Storage: shading, confined preservation.
Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery.
Tamoxifen is also used to treat hormonally-responsive breast cancer, but it does so by interfering with the estrogen receptor. However, letrozole is effective only in post-menopausal women, in whom estrogen is produced predominantly in peripheral tissues (i.e. in adipose tissue, like that of the breast) and a number of sites in the brain. In pre-menopausal women, the main source of estrogen is from the ovaries not the peripheral tissues, and letrozole is ineffective.


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