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Melanotan II, also known as Melanotan 2, MT2, MT-2, and MT-II, is a peptide designed to replicate the structure and properties of a naturally occurring hormone known as melanocyte-stimulating hormone (MSH). MSH plays a role in skin pigmentation, energy balance, sexual function, the immunological system, inflammation, and cardiovascular function.

Melanotan II (MT2) is comparable to Melanotan I (Afamelanotide) and Scenesse, which are FDA authorized as an under-the-skin implant for the prevention of phototoxicity in individuals with Erythropoetic Protoporphyria.

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MT2 was first developed in the 1980s by University of Arizona researchers, who were looking to clarify the nature and role of the melanocortin receptors in physiological functions. Namely, the peptide was intended to be used as a sunless tanning agent, but was subsequently found to strongly affect sexual function and appetite.

Melanotan 2 (MT-II) should not be confused with another α-MSH analogue, melanotan I (MT-I), which is a linear peptide of 13 amino acids in length. MT-I is identical to α-MSH except that it features norleucine instead of methionine in the fourth position, and D-phenylalanine instead of L-phenylalanine in the seventh position.In contrast, MT II is a cyclic truncated peptide of just seven amino acids and features a lactam ring.

What are the possible benefits of Melanotan II(MT2)?
Melanotan II has been formally investigated in clinical trials for tanning and erectile dysfunction benefits. However, research into melanocortins and MT-II is still ongoing, and there is a substantial and rising body of evidence pointing to a wide range of additional physiological activities that MT-II can beneficially affect. For your convenience, below are some probable MT-II benefits:

Melanogenesis is a process that results in tanning.
Phototoxicity protection, i.e. photoprotective in persons with Erythropoietic Protoporphyria
Enhances libido
Increases immunity by activating Treg cells and improving Th1/Th17 balance
Reduces inflammation in chronic conditions such as ulcerative colitis, irritable bowel syndrome, and Crohn’s disease.
Lowers appetite while improving lipid and glucose regulation
Neuroprotective through reducing neuroinflammation after brain injury, brain ischemia, spinal cord damage, and increasing peripheral nerve regeneration ability in post-lesion healing.
Potential usage in the misuse of alcohol and drugs, including opioids and cocaine (reward cascade supportive).
Enhance cardiovascular benefits such as anti-inflammation, reperfusion, and blood pressure increase.

How does Melanotan II(MT2) Work on our body?
Melanotan II is up to 1000 times more powerful than endogenous -MSH, attaching to melanocortin receptors to various degrees and causing a variety of effects. Melanotan-II (MT2) works by interacting with specific receptors in the body, primarily the melanocortin receptors, to produce its effects. Here is a list of the receptors involved:

MC1R: Melanocytes, which produce pigment in the skin, hair follicles, and eyes, are the primary cells that express MC1R. The activation of MC1R by alpha-melanocyte-stimulating hormone (-MSH) promotes melanin production and distribution, resulting in skin and hair pigmentation.

MC2R: It is present mostly in the adrenal glands, specifically in the outer layer known as the adrenal cortex. It is essential for the generation and release of cortisol, a hormone implicated in stress reactions and a variety of metabolic activities.

MC3R: It is found throughout the central nervous system, including sites important in hunger regulation and energy balance, such as the hypothalamus. It is also prevalent in peripheral tissues such as the GI tract and adipose tissue.

MC4R: It is found mostly in the brain, notably in areas linked with hunger control, such as the hypothalamus. It is essential for controlling food intake and energy expenditure. Mutations in the MC4R gene have been linked to inherited forms of obesity.

MC5R: MC5R is found in a variety of tissues, including the skin, hair follicles, immune cells, and exocrine glands. Its precise roles are currently being researched.

It is worth noting that the MC1R is nearly entirely a pigment receptor that is present on cells where pigmentation is known to be significant, such as the eyes. To avoid the sunless tanning characteristics of melanocortins, it would be critical to avoid binding to this receptor. Though MT2 binds to MC1R with less affinity than MT1 or -MSH, it nevertheless binds and causes skin pigmentation.

The MC3R, like the MC4R, is broadly distributed in the central nervous system. These two receptors are expected to be of considerable importance in the future since they are most likely to govern the effects of melanocortin on things like behavior. One of the primary goals of melanotan 2 and other melanocortin research is to understand how these receptors work and how they may be precisely targeted.

What is the Potential Risks of Injecting Melanotan II(MT2)?
MT-II may bring some risks when we inject Melanotan II(MT2), it has been considered minimal and are normally only felt for a short period of time after administration, with the frequency and severity of symptoms being proportional to dosage.

Following administration, the following short-term adverse effects may occur:

▪ Flushing of the face

▪ Appetite suppression, nausea, and vomiting

▪ Spontaneous erections (priapism) in males 1-5 hours after injection, associated with yawning and stretching complicated

There is some worry that melanotan II may raise the risk of:

▪ Melanoma is a potentially fatal type of skin cancer.

▪ Mole coloration changes, new moles, and atypical melanocytic naevi

▪ Melanonychia is a discoloration of one or more nails that ranges from brown to black.

▪ Rhabdomyolysis is the potentially deadly breakdown of muscle cells.

▪ Syndrome of Encephalopathy

Concerns have also been raised about potential side effects caused by contamination or a lack of sterility if melanotan II is prepared incorrectly or needles are shared. In summary, if MT-II is properly dosed, it is a safe and well-tolerated compound that causes only minor symptoms that typically resolve shortly after administration.

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