S-adenosylmethionine Powder/[email protected]

Description

S-adenosylmethionine (also called SAMe) is a naturally occurring chemical in the body. S-Adenosyl Methionine is the amino acid methionine bound to an ATP molecule; this molecule circulates in the blood naturally and acts as a 'methyl donor'.

SAMe plays a role in the immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine. It works with vitamin B12 and folate (vitamin B9). Being deficient in either vitamin B12 or folate may reduce levels of SAMe in your body.

Benefits

SAMe appears to follow many nutrient-like motifs in the body, being regulated within a certain serum range and being associated with adverse effects when that range is perturbed. It potentially holds a lot of benefit in body states where circulating SAMe levels decline.

S-adenosylmethionine has been used in alternative medicine as an aid to treating depression, osteoarthritis, fibromyalgia, and liver problems.

Some body states appear to be associated with lower circulating levels of SAMe, including osteoarthritis and depression where SAMe appears to hold potent therapeutic potential; after a build-up period of 1-2 months, supplemental SAMe at 800-1600mg daily appears to be as potent as some pharmaceutical options for both osteoarthritis and depression and appears to enhance some anti-depressants. Although lower circulating levels of SAMe are also seen in diabetes, the benefits of SAMe and glucose control are not as well established as depression and osteoarthritis.

Dosage

Supplementation of S-adenosylmethionine tends to be in the 600-1,200mg range over the course of a day, divided into two or three separated doses with meals. The higher dosage (1,200mg) tends to be used more often, with the lower dosage (600mg) being used to cut costs.

For S-adenosylmethionine to benefit osteoarthritis, it appears to require a few weeks or up to a month of continual usage for benefits to show. Benefits to depressive symptoms may be much more rapid.

Side Effects

Although side effects are not commonly reported with SAMe, numerous studies note a small set of participants who experience mania after supplementing SAMe. It is not common, but it does appear to be related to SAMe supplementation for unknown reasons; it has been reported in some persons without history of mania as well and does not appear to be related to any pathological condition per se.