Podophyllotoxin

Synonyms: Podophyllic Acid Lactone; podofilotoxina (Spanish); Condylox.

Description: Podophyllotoxin (abbreviated as PPT), otherwise known as podofilox, is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species. Under the trade name Condylox, a topical gel, it is used on the skin to treat external genital warts, caused by some types of the human papillomavirus (HPV). PPT and its derivatives display a wide selection in medical applications such as purgative, vesicant, antirheumatic, antiviral, and antitumor agents. These derivatives include etoposide, teniposide, and etopophos. Their anticancer activity has been heavily under study and used in various chemotherapies, including lung cancer, lymphomas, and genital tumors.

Product Source: Podophyllum peltatum.

Part used: Root and Stem

Chemical Name: (10R,11R,15R,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo [7.7.0.0.01] hexadeca-1,3(7),8-trien-12-one

CAS No.: 518-28-5; 4354-76-1

Molecular Formula: C22H22O8

Molecular Weight: 414.41

Appearance: White needle crystalline powder.

Melting Point: 178-184℃ .

Boiling Point: 597.9°C at 760 mmHg.

Test Method: HPLC.

Specification: 98%, 99%.

Function: Expelling wind and removing dampness, arresting cough, relieving the pain, promoting blood circulation and relieving toxin. It is used for rheumatic arthralgia, the injury due to falling, cardialgia and stomach ache, cough due to pathogenic wind-cold, irregular menstruation.

Package: Double plastic-bag inside, aluminum foil bag paper or fiber drum outside. N.W: 25kg/drum

Storage: Store in cool and dry place and avoid light and heat.

Shelf Life: 2 years