Palmitoyl Tripeptide-28

INCI name: Palmitoyl Tripeptide-28
Reference: ECM Moduline peptide
Source: synthetic
Solubility: soluble in water
Stability: stable
Purity: ≧95%
Grade: cosmetic
MSDS and COA: available for your reference, please contact us
Capacity: 1kg per month
Appearance: white powder
2.Functions: Palmitoyl Tripeptide-28 improves skin elasticity & firmness and serves as an anti-inflammatory.
3.Introduction:
Palmitoyl Tripeptide-28 binds with the specific receptor TGF-bII (TbRII) at the cellular surface. This receptor phosphorylates the receptor TGF-bI (TbRI) to generate an active receptors complex so they phosphorylate the protein Smad 2 or Smad 3.Smad 2 or Smad 3 form a complex withthe protein citoplasmatic Smad 4 and this allows the translocation of the Smad complex into the nucleus. There, the booster Smad complex binds with specific sequences of the promoters of the extracellular matrix genes that activate its expression.

Palmitoyl Tripeptide-28 is the key in the regeneration of extracellular matrix as it stimulates the proteins synthesis in the extracellular matrix, inhibits the metalloproteinases that degrade the collagen, stimulates the production of proteases inhibitors and the synthesis of integrins.