Naringenin/[email protected]

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Naringenin is a bitter,colourless flavanone, a type of flavonoid. It is the predominant flavanone in grapefruit, and is found in a variety of fruits and herbs.


Usages

Antibacterial, antifungal, and antiviral
Naringenin's potential antibacterial and antifungal behaviour has been investigated. Naringenin was shown to indeed have an antimicrobial effect on S. epidermidis, as well as Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, and Escherichia coli.Further research has added evidence for antimicrobial effects against Lactococcus lactis,lactobacillus acidophilus, Actinomyces naeslundii, Prevotella oralis, Prevotella melaninogencia, Porphyromonas gingivalis, as well as yeasts such as Candida albicans, Candida tropicalis, and Candida krusei.There is also evidence of antibacterial effects on H. pylori, though naringenin has not been shown to have any inhibition on urease activity of the microbe.

Naringenin has also been shown to reduce hepatitis C virus production by infected hepatocytes (liver cells) in cell culture. This seems to be secondary to naringenin's ability to inhibit the secretion of very-low-density lipoprotein by the cells.The antiviral effects of naringenin are currently under clinical investigation.Reports of antiviral effects on polioviruses HSV-1 and HSV-2 have also been made, though replication of the viruses has not been inhibited.