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Lipospondin
Price: | US$ 100 / Carat |
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Payment Terms: | T/T |
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Product Details
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Name: Lipospondin Formula: C21H35N5O4 Molecular:685 Sequence: N-Elaidoyl-KFK Purity: ≧95% Grade: cosmetic Source: synthetic Stability: stable Appearance: white powder MSDS and COA: available for your reference Delivery: promptly from stock |
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Product Description
Name: Lipospondin Formula: C21H35N5O4
Molecular:685
Sequence: N-Elaidoyl-KFK
Purity: ≧95%
Grade: cosmetic
Source: synthetic
Stability: stable
Appearance: white powder
MSDS and COA: available for your reference
Delivery: promptly from stock
2.Usage: prevent age-associated dermal alterations防止年龄相关的皮肤改变
3.Description:N-Elaidoyl-KFK as well as KFK were shown to activate LAP-TGF-beta both in vitro, using a solid phase assay with immobilized LAP-TGF-beta, and ex vivo using human dermal fibroblasts cultures. In both assays, as much as up to 10% of LAP-TGF-beta added could be recovered as active form. KQK, KQFK as well as their lipopeptide counterparts were inactive. Elaidyl-KFK-mediated LAP-TGF-beta activation led to up-regulation of collagen and TIMP-1 production and down regulation of PMA-induced MMP-1 expression in fibroblasts cultures. Those effects could be suppressed by supplementing cell culture medium with blocking TGF-beta antibody. Elaidyl-KFK inhibited MMP-2, MMP-9, MMP-3, MMP-1, in vitro with IC(50) equal to 1.2, 1.0, 0.24 and 8.9 microM, respectively. Its ex vivo inhibitory capacity, as assessed using skin tissue sections, towards the elastin-degrading capacity of MMP-9 was even more pronounced. At a 1 microM concentration, the lipopeptide decreased by up to 80% enzyme activity. Thus, "Lipospondin," i.e. elaidyl-KFK might be considered as a promising model compound to prevent age-associated dermal alterations.
SUPPLIER PROFILE
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Company: | Chengdu Youngshe Chem Co., Ltd | ||
City/State | Chengdu, Sichuan | Country: | China |
Business Type: | Export - Manufacturer / Trading Company | Established: | 2015 |
Member Since: | 2022 | Contact Person | Leslie Cheng |
SUPPLIER PROFILE
City/State/Country -
Chengdu, Sichuan
China
Business Type -
Export - Manufacturer / Trading Company
Established -
2015
Member Since -
2022
Contact Person -
Leslie Cheng