Human Kupffer Cells

Isolated and enriched from dissociated human liver tissue, Human Kupffer cells (HKC) are the resident macrophages in human liver. Kupffer cells are the densest innate liver immune cells and the first line of defense against bacteria and toxins in the intestine. Liver Kupffer cells have typical macrophages abilities like modulating hepatic inflammation and injury. Activated hepatic Kupffer cells could release inflammatory cytokines, growth factors and reactive oxygen species.
In vivo, the activation of Kupffer cells could mediate inflammation that develop into liver diseases such as Non-Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH), and liver damage associated with certain bioactivated chemicals.

Kupffer Cells Applications
Co-culturing with other cells to mimic lacking in vitro models for analyzing immune-mediated drug-induced hepatotoxicity
In vitro drug metabolism and pharmacokinetics (DMPK) assays
Investigation of cytokine releases that response to inflammation
Chronic liver injury research
Human Kupffer Cells are proved to be inducible with lipopolysaccharide (LPS) with the evaluation. Human Kupffer Cells also keep high activation potential.