Human Hepatocytes

Human Hepatocytes (HH) are hepatic cells isolated from the whole human liver, making up 80% of the liver’s mass. Liver hepatocytes are multifunctional. Hepatocyte involves in the production and synthesis of functional proteins that participate in energy metabolism, biotransformation, detoxification, etc. Hepatocytes secrete many materials including structural protein and intracellular enzymes, cholesterol, bile, detoxify substances. Understanding the molecular mechanisms of the liver is beneficial to elucidate new therapies for treatment of hepatic disease.
Primary hepatocyte cultures are unable to expand, which is challenging for long-term research on understanding the regulation of human hepatocytes.

Application
Constitute a more predictive model for pharmaceutical research
Drug metabolism study, including clearance, hepatotoxicity, drug-drug interactions
CYP enzymes expression or inhibition studies
3D co-culture