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Human GRPR/Galpha15 Stable Cell Line-Chem-1
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  • Human GRPR Galpha15 Stable Cell Line
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Human GRPR/Galpha15 Stable Cell Line-Chem-1

Price: US$ 1 / Gram
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Product Details
Model No.: Brand Name: Creative Biogene
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Specification: Human GRPR/Galpha15 Stable Cell Line-Chem-1
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Product Description
Bombesin, a bioactive peptide first identified in amphibian skin, is related to two mammalian peptides, gastrin-releasing peptide (GRP) and neuromedin B. A family of 3 GPCRs, including NMB-R (BB1), GRP-R (BB2) and BRS-3 (BB3), mediate the biological effects of the peptides. The receptors differ in their affinities for the peptides; BB2 binds to GRP with 50-300-fold greater affinity than to NMB, whereas BB1 binds to NMB with 10-800-fold greater affinity than to GRP. Binding of ligand to BB2 activates Gq to increase intracellular calcium concentrations. GRP stimulates release of gastrin from endocrine cells and stimulates smooth muscle activity in the gastrointestinal tract. In addition, binding of GRP to BB2 stimulates proliferation of a variety of cell types, and has been implicated in the progression of small cell lung cancer and other malignancies. The CNS is also a major site of GRP expression, and GRP and BB2 are involved in the circadian clock, conditioned fear, and food intake.
creative-biogene.com/Human-GRPR-Galpha15-Stable-Cell-Line-Chem-1-195517-11.html
Human GRPR/Galpha15 Stable Cell Line-Chem-1
SUPPLIER PROFILE
Company: Creative Biogene
City/State Shirley, NY Country: United States  
Business Type: Export/Import - Trading Company Established: 2005
Member Since: 2017 Contact Person Wendy Wilson
SUPPLIER PROFILE
City/State/Country -
Shirley, NY
United States  
Business Type -
Export/Import - Trading Company
Established -
2005
Member Since -
2017
Contact Person -
Wendy Wilson