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Human CASR/Galpha15 Stable Cell Line-Chem-1
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Human CASR/Galpha15 Stable Cell Line-Chem-1

Price: US$ 1 / Gram
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Product Details
Model No.: Brand Name: Creative Biogene
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Specification: Human CASR/Galpha15 Stable Cell Line-Chem-1
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Product Description
Calcium homeostasis in vertebrates is regulated by hormonal communication between the parathyroid and thyroid glands, kidney, bone, and intestine. A central mediator of this regulatory system is the calcium sensor CaS (also known as CaR), a class III GPCR that is activated by high concentrations of extracellular calcium and other divalent cations. The cell types that are responsive to variations in blood calcium concentration express CaS and respond to changes in extracellular calcium in a CaS-dependent fashion. Activation of CaS in parathyroid chief cells inhibits PTH release, which results in decreased calcium mobilization from bone. In contrast, stimulation of CaS activity in the C cells of the thyroid increases secretion of calcitonin, which causes decreased bone resorption and increased urinary excretion of calcium. Allosteric "calcimimetic" potentiators are being evaluated for treatment of primary hyperparathyroidism.
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Human CASR/Galpha15 Stable Cell Line-Chem-1
SUPPLIER PROFILE
Company: Creative Biogene
City/State Shirley, NY Country: United States  
Business Type: Export/Import - Trading Company Established: 2005
Member Since: 2017 Contact Person Wendy Wilson
SUPPLIER PROFILE
City/State/Country -
Shirley, NY
United States  
Business Type -
Export/Import - Trading Company
Established -
2005
Member Since -
2017
Contact Person -
Wendy Wilson