High Quality Nootropic Powder Nefiracetam/[email protected]

Nefiracetam is a cognitive enhancer (nootropic) of the racetam class, derived initially from the parent molecule piracetam but it shares most structurally similarity to aniracetam. Nefiracetam is fat soluble racetam drugs for the purpose of memory enhancement or the treatment of cognitive decline.

Benefits of Nefiracetam

1. Memory. One of the primary Nefiracetam benefits is better memory and information retention in the long term.

2. Learning Ability. There have been studies showing that this supplement can lead to improvements in spatial learning abilities. Nefiracetam also has a much more potent effect on increasing attention spans, concentration and focus as compared to other nootropics like Pramiracetam, Oxiracetam or Piracetam.

3. Healthy Brain Cells. It may also be helpful in treating patients with cognitive decline as well as improving the health and maintenance of your brain cells. Taking Nefiracetam is thought to actually protect brain neurons from premature cell death due to cytoprotective actions.

4. Stress, Anxiety, Depression. Nefiracetam has been found useful for reducing stress, anxiety, and even depression. The mechanisms of action for these supplements are similar in many respects, but Nefiracetam seems to exhibit a wider range of effects.

5. Seizures. Studies also indicate that this supplement might be effective in treating seizures. This includes both convulsive and non-convulsive seizures. The primary effect is to greatly reduce the effects of amygdala based seizures and use for stroke patients in reducing the number and duration of post-stroke seizures.

6. Alzheimer's and Dementia. May have a therapeutic role in Alzheimer's and Dementia, but this has not been well investigated. Preliminary evidence seems promising

Memory Mechanisms of Nefiracetam

The memory mechanisms of nefiracetam seem to be linked back to two pathways. One is prolonging the opening of calcium channels which enhances signalling of a receptor independent of the synapse, and the other pathway seems to be tied into PKC and CAMKII which then augments signalling through cholinergic receptors. The former pathway appears to be critical for long-term potentiation, whereas the latter pathway appears to be vital for neuronal signal enhancement.

Some other minor pathways include being a partial agonist at the glycine binding site of the NDMA receptor (may enhance signalling when there are subpar levels of glycine, but attenuates excessive signalling) and increasing affinity of the muscarinic acetylcholine receptors for its ligand, acetylcholine.

Side Effects

Nefiracetam side effects are those typically associated with other Racetams. These include headaches, nausea, irritability, fatigue, dizziness, and stomach issues. The headaches can be easily overcome by taking a high quality Choline supplement like Alpha GPC or Centrophenoxine.

Toxicity of Nefiracetam

In regards to the potential toxicity of nefiracetam, it does appear to be reliably toxic in dogs at doses that are much higher than the recommended supplemental dosage; lower doses seem to be free from toxicity, and these lower doses barely fit into the recommended dosage range.

That being said, there is evidence to suggest that this toxicity is exclusive to canines as it has not been detected in rats nor monkeys. There is insufficient human testing to absolutely confirm that it isn't a concern for humans, but the limited human evidence at this point in time using the recommended nefiracetam dosages do not find any significant complications.