Fragment 177-191 / AOD-9604 CAS 12629-01-5 Weight Loss Steroid AOD9604

Abstract

AOD-9604 is a peptide fragment of the C-terminus of to which a tyrosine is added at the N-terminus. Studies have suggested that AOD-9604 is more effective than its predecessor AOD-9401 in its ability to stimulate lipolytic and anti-lipogenic activity. AOD-9604 stimulates lipolysis (the breakdown of fat) and inhibits lipogenesis (prevents the transformation of fatty food materials into body fat) both in laboratory testing and in animals. In laboratory tests on fat cells from rodents, the fragment released fat specifically from obese fat cells and reduced new fat accumulation in all fat cells.

These segments of the synthetic peptide AOD9604 have been researched for their in vivo effects in laboratory mice musculus. Results have shown that AOD9604 have resulted to a short-period increase in blood glucose and a more sustained increase in plasma insulin, together with other fragments such as 172-191, 177-191 and 178-191.

In addition, the researchers have suggested that functionality of the peptide depends not only in the informational sequence but should also have the correct physical configuration (Ng and Borstein 1978). Also, AOD9604, being a region of high accessibility to proteases and also rich in proline, have been demonstrated to affect the conformational change in the cytoplasmic domain of the band 3 of erythrocyte membrane protein by serving as the hinge for the pivoting of the two subdomains. This then suggest that such residue is significant in conformational changes be serving as sites for peripheral protein binding in some body cells (Low et al. 1984).


Uses

1. Reduces the most stubborn abdominal fat.
2. Increases muscle mass
3. Increases energy expenditure
4. Improves lipid profiles and lipolytic activity does not negatively impact blood glucose level, nor does cell proliferation occur, like Human Extremely potent and effective fat burner.