Formestane Anabolic Steroid Hormones 4-Hydroxyandrost-4-ene-3 17-dione CAS NO 566-48-3

Quick Details:
Production Name: Formestane
Alias: Lentaron; 4-Hydroxy-4-androstenedione; 4-Hydroxyandrostenedione
CAS No: 566-48-3
Einecs No: 219-112-8
MF: C19H26O3
MW: 302.41.
Purity: 99.0%min
Original: China
Appearance: white crystalline powder
Product Description:
1. Formestane (Lentaron) is a type I, steroidal aromatase inhibitor. It is used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. It is available as an intramuscular depot injection. Formestane has poor oral bioavailability and as such is no longer popular as many orally active aromatase inhibitors have been identified. It is used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. The drug is not active orally, and is instead available only as and intramuscular depot injection. Because of this, it is no longer popular as many orally active aromatase inhibitors have been identified and introduced. Formestane is an analogue of androstenedione.
2. Formestane is often used to suppress the production of estrogens from anabolic steroids or?prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a weak aromatase inhibitor.
3. Formestane is a androstenedione derivative, and it belongs to an aromatase inhibitor with aminoglutethimide, it is a hormone antineoplastic agent. In physiological conditions, it may competitively inhibit the synthesis of the enzyme leading to estrogen biosynthesis decrease in tissues, then it plays its role in cancer. When the tumor tissue growth relies on the presence of estrogen, in order to inhibit tumor growth, the elimination of tumor estrogen-mediated growth stimulation is necessary.
4. This product is more selective than aminoglutethimide while its activity is 100 to 1000 times of aminoglutethimide, and it does not inhibit the synthesis of adrenal hormones, without having to recharge cortisone, etc . The in vitro inhibition of aromatase enzyme of this product is 60 times stronger than aminoglutethimide.
COA:
Product name Lentaron
Appearance White crystalline powder
Assay(*) 98~101.0% 99.2%
Identification By UV, To match with working standard Complies
Related Substances Not more than the reference solution (0.05%) Complies
Heavy metals ≤20ppm 10ppm
Loss on drying <0.5% 0.1%
Resiue on ignition ≤0.1% 0.05%
Melting 199-202®C 200®C
Leading time:within 24 hours upon receipt of payment
Certification:SGS, ISO 9001, KOSHER
Package:1kg/foil bag.Discreet and Hidden package according to specific requirement
Delivery:Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Usage: It is primarily used for the treatment of postmenopausal women with advanced breast cancer, it is also effective in prostate cancer.
Minimum Order Quantity: 5g
Price: Negotiable
Payment Terms: Western Union, Money Gram , T/T, Bitcoin
Application:
1. Formestane also known as lentaron,is an anti-cancer drug, it is primarily used for the treatment of postmenopausal women with advanced breast cancer, it is also effective in prostate cancer;
2. While it is used alone, the drug can not significantly reduce the pre-menopausal estrogen levels in the blood of women,when it is combined with goserelin (gonadotropin-releasing hormone agonist), its inhibitory effect of estrogen in premenopausal women is greater than goserelin used alone.
3. Formestane has no cross-resistance with other aromatase inhibitors , it has no side effects of aminoglutethimide. After oral administration,it is rapidly absorbed by gastrointestinal, its peak plasma concentration time is 1 to 1.5 hours, but the peak concentration of individual is of great difference; after intramuscular injection, it can be accumulated at the injection site and be slowly absorbed.
4. It performs Biphasic elimination process, the initial elimination half-life is 2 to 4 days, the terminal elimination half-life is 5 to 10 days. It is mainly metabolized in the liver after oral administration, in the form of glycosides acid metabolites excreted in the urine.
Competitive Advantages:
1. Wuhan Carnoss Technology Co., LTD. is not only the leading manufacturer of steroids powder and pharmaceutical raw materials in the central area of China, but also a leading export company with product sold to all over the world. All our products are factory directly supplying.
2. Our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
3. Our products are of high quality at competitive prices.
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