Dapoxetine HCL [email protected]

1. Treat male premature ejaculation and erectile dysfunction., marketed as (among and other brands) is the first compound developed specially for the treatment of premature ejaculation (PE) for men at the age of 18-64 years old. works by inhibiting the serotonin transporter, increasingserotonin’s action at the post synaptic cleft, so as to delay ejaculation.. As a member of selective serotonin reuptake inhibitor (SSRI) family, was initially created as an antidepressant. However, unlike other SSRIs, is absorbed and eliminated rapidly in the body. Its fast response makes it suitable for the treatment of PE but not as an antidepressant.


2. Due to the lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as Fluoxetine, Paroxetine, Sertraline, Fluvoxamine, and Citalopram have been used as clinical drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increases IELT from two to nine times above base line in comparison of three to eight times when is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence an increased adverse effects such as decreasing sexual libido and causing erectile dysfunction. , on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.


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