CAS 57808-66-9 Domperidone

CAS NO.: 57808-66-9
Other Names: Domperidon
MF: C22H24ClN5O2
EINECS NO.: 260-968-7
Type: Gastrointestinal Agents
Grade Standard: Medicine Grade
Usage: Animal Pharmaceuticals
Purity: 99%min
Appearance: White Crystalline Powder
CAS No.: 57808-66-9
Molecular Formula: C22H24ClN5O2
Appearance:White Powder
Benzimidazole compounds - domperidone is, with prokinetic and antiemetic effect of strong, can strengthen the lower esophageal sphincter tension, prevent gastroesophageal reflux, enhance gastric peristalsis, promote gastric emptying, stomach and duodenal motor coordination, nausea, vomiting, and effectively prevent the bile reflux, does not affect the secretion of gastric juice

Molecular Formula C22H24ClN5O2
Synonyms
domperidone

57808-66-9

Motilium

Nauzelin

Domperidonum

Domperidone is a peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons; this inhibits dopamine binding and D2R-mediated signaling. Inhibition of peripheral D2R signaling prevents or relieves various gastrointestinal (GI) symptoms, such as nausea and vomiting, and may help relief reflux and symptoms of a variety of other upper GI disorders.

Domperidone is 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations. It has a role as an antiemetic and a dopaminergic antagonist. It is a member of benzimidazoles and a heteroarylpiperidine.

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