Best Quality Smart Drugs DM-235 Sunifiram/[email protected]

Sunifiram is one of the newest nootropics on the market to smart drugs family. It provides a wide variety of benefits including; increased attention span, improved focus, and increased learning potential. It has become very popular since its release, as the benefits are high and the side effects are low. In terms of its potency, it's comparable to Noopept.

Benefits of Sunifiram

Based on research and user reviews, the benefits are plentiful. There is a range of benefits, all relating to cognitive enhancement. This is why Sunifiram has been popular amongst students. It increase one's ability to focus, as well as recall information.

Sunifiram increases energy levels, allowing users to feel more motivated and eliminate procrastination. Users report being more goal-oriented, wanting to get things done. This is popular amongst students or employees, as it does not create the negative side-effects like Ritalin or Adderall do. This increase in energy levels and attention span, are the result of increased glutamate activity.

Levels of concentration increase, and users feel less distracted by external stimuli. Once again, this makes it effective when studying. Certain employees would also benefit, especially in such a competitive career world.

There have been a lot of studies conducted regarding memory. Most benefits are seen regarding short-term memory or working memory. The level of recall dramatically increases, as some users have reported hearing information once and recalling it hours later. Early research showed that Sunifiram also enhances long-term potentiation, which is the forming of new connections regarding memory storage.
Levels of anxiety are reduced, as Sunifiram has some anxiolytic benefits. Feeling more relaxed is beneficial when trying to focus.

Mechanisms

1. Sunifiram activates AMPA-mediated neurotransmission.
2. It enhances LTP in a bell-shaped dose-response relationship. This enhancement by sunifiram is associated with an increase in phosphorylation of AMPAR through activation of protein kinase II (CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCα activation through Src kinase. Enhancement of PKCα activity triggers hippocampal LTP through CaMKII activation.
3. Sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation. PKC activation may be a common mechanism amongst cognition stimulating drugs from different chemical classes.
4. Sunifiram aids in the release of acetylcholine in the cerebral cortex.

Stacking

Sunifiram can be stacked with other nootropics, but users are cautioned to be both careful and conservative about sunifiram dosages in combination with other potent supplements, particularly until they’re sure how they react to sunifiram.

Stacking for enhanced cognitive effects: This is possibly the most common type of sunifiram stack and is best accomplished by pairing sunifiram with one or more of the racetams like piracetam, oxiracetam, or Noopept. Because racetams make a powerful draw on the brain’s choline stores, it’s important to add a good choline source like CDP choline, Alpha GPC, or centrophenoxine to this type of stack.

Stacking for mood enhancement: Aniracetam is known to stack well with sunifiram for mood enhancement. L-theanine, which enhances production of dopamine, serotonin, and GABA and acts as glutamine reuptake inhibitor, also stacks well with sunifiram. Sulbutiamine, which potentiates cholinergic, dopaminergic, and glutamatergic transmission, is another good addition to this type of stack. As always when a racetam supplement is used, a good choline source is important both as a potentiator and to prevent headaches and other unwanted side effects.

Recommended Dosage

This is a highly potent substance, so you should start with doses as small as 3 to 4 mg. The average user will take between 5 and 8 mg. If you take 10 mg or more, you will experience a stimulant effect closer to Adderall.
As mentioned, start with small doses and increase your dosage after a week or so. If you have any concerns about dosage, speak with your doctor. Reviews are very helpful, as they recall first hand experience.

Side Effects

User reported side effects are both minor and temporary and include an increase in body temperature, increased perspiration and salivation, headache, nasal stuffiness, increased sensitivity to visual and audio stimulation, and insomnia.