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BV-2
Price: | US$ depends |
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Minimum Order: | |
Payment Terms: | L/C |
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Product Details
Model No.: | ABC-TC212S | Brand Name: | AcceGen |
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AcceGen BV-2 cells are positive for MAC1 and MAC2 antigens, negative for MAC3, glial fibrillary acidic protein (GFAP) and galactocerebroside (GC). Key Features -Backed by AcceGen advanced technology -Cryopreserved for highest viability and plating efficiency -Quality-tested for accurate results |
Packaging & Delivery
Packaging: | dry ice |
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Product Description
BV-2 Cells Derivation and biomarker BV-2 is a type of microglial cell derived from C57/BL6 murine. The BV2 cells are immortalized by v-raf /v-myc carrying J2 retrovirus. BV2 express nuclear v-myc and the cytoplasmic v-raf oncogene products as well as the env gp70 antigen at the surface level. BV2 microglia cell line retains microglia morphological and functional characteristics. In accordance with v-raf/v-myc expressed characters, the metabolic and proliferation rate of in vitro BV-2 greatly exceeds that of other microglia.
BV-2 Cells Application and example model
In the central nervous systems (CNS), microglial cells are resident macrophages. BV-2 shares properties with body macrophages with respect to the antigen profile, their phagocytic capacity and antimicrobial activity. Like other microglia, BV-2 can be activated to release pro-inflammatory cytokines by oxidative stress or inflammatory factors. Such stimulus possibly triggers neurodegenerative disorder such as Alzheimer and Parkinson disease, thus BV-2 is widely used as an alternative model system for primary microglia and neurodegenerative disease model in vitro. The model is usually induced by Lipopolysaccharide (LPS) treatment.
SUPPLIER PROFILE
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Company: | AcceGen Biotechnology | ||
City/State | Fairfield, NJ | Country: | United States |
Business Type: | Export - Manufacturer / Trading Company | Established: | 2016 |
Member Since: | 2021 | Contact Person | AcceGen Biotech |
SUPPLIER PROFILE
City/State/Country -
Fairfield, NJ
United States
Business Type -
Export - Manufacturer / Trading Company
Established -
2016
Member Since -
2021
Contact Person -
AcceGen Biotech