Acetyl-resveratrol

Appearance: White to off-white powder

Test Method: HPLC

Molecular Formula: C20H18O6

Molecular Weight: 354.35

CAS No: 42206-94-0

Description: Acetyl-resveratrol is called prodrug on medicinal
chemistry, it is more stable than trans-resveratrol. When absorbed, it
returns to resveratrol under action of metabolism.

The main drawback with current resveratrol forms is the low oral
bioavailability. Resveratrol is water-insoluble substance; it can be
easily excreted when intaked. This is why finding these acetylated
analogs has been so significant; they have better bioavailability and
increased biological activity in comparison to the base phenolic
compounds. Multiple studies have shown that acetylated analogs of
Resveratrol exhibit the same or higher inhibitory effects on various
tumor cell lines than Resveratrol itself while being absorbed faster and
resisting cellular breakdown. Since the acetylated Resveratrol is being
absorbed more quickly, plasma levels in the body reach a higher level
and at a faster rate. Through ester hydrolysis enzymes in the body
actually break down acetylated Resveratrol back to its natural phenolic
form.

Dosage form varied from pill to capsule up to different requirements
when use Acetyl-resveratrol as raw material.

Resveratrol is unstable because its Hydroxyls are active group when
exposure to oxygen, light and heat. The purpose of acetylation is to
inactivate Resveratrol before absorption.

Acetyl-resveratrol is soluble in water (but not resveratrol). Therefore, it
can be widely used in cosmetic industry, pharmaceutics, food,
beverage, health products.