AZD-9291

Product name:AZD-9291
AZD-9291
Other Names: N(2{[2(diMethylaMino)ethyl](Methyl)aMino}4Methoxy5{[4(1Methyl1Hindol3yl)pyriMidin2yl]aMino}phenyl)prop2enaMide;N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide;AZD9291,AZD-9291
CAS: 1421373-65-0
Molecular formula: C28H33N7O2
Molecular weight: 499.61
Standard: Medical grade
Purity: 99%
Appearance: white powder
Packing: 25KG / cardboard drum can be split
Category: Pharmaceutical raw materials
Industry: Medicine
Area: Inhibitors
Extension products: tablet capsules
Use: Oral medications in patients with advanced non-small cell lung cancer (NSCLC)
AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 μM, respectively). AZD 9291 has been shown to inhibit tumor growth in a xenograft mouse model at oral doses of 5-10 mg/kg and has been tested clinically in patients with advanced EGFR mutant non-small-cell lung cancer.