4-tert-Butylbenzenesulfonamide

Tert. Butyl Benzene Sulphonamide;BUTTPARK 44\03-78;4-TERT-BUTYLBENZENESULFONAMIDE;4-TERT-BUTYLBENZENESULPHONAMIDE;4-(TERT-BUTYL)BENZENE-1-SULFONAMIDE;P-TERT-BUTYL-BENZENESULFONAMIDE;TertiaryButylBenzeneSulphonamide;4-(1,1-DIMETHYLETHYL)BENZENESULFONAMIDE
Chemical Properties White solid
Uses 4-tert-Butylbenzenesulfonamide is an intermediate as well as a degradation impurity of the endothelin receptor antagonist Bosentan (B675900).
Product Name: 4-tert-Butylbenzenesulfonamide
Synonyms: Tert. Butyl Benzene Sulphonamide;BUTTPARK 44\03-78;4-TERT-BUTYLBENZENESULFONAMIDE;4-TERT-BUTYLBENZENESULPHONAMIDE;4-(TERT-BUTYL)BENZENE-1-SULFONAMIDE;P-TERT-BUTYL-BENZENESULFONAMIDE;TertiaryButylBenzeneSulphonamide;4-(1,1-DIMETHYLETHYL)BENZENESULFONAMIDE
CAS: 6292-59-7
MF: C10H15NO2S
MW: 213.3
EINECS: 613-109-9
Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 6292-59-7.mol
Melting point 136-138®C
Boiling point 337.2¯35.0 ®C(Predicted)
density 1.152¯0.06 g/cm3(Predicted)
pka 10.22¯0.10(Predicted)
InChIKey KYDZEZNYRFJCSA-UHFFFAOYSA-N
CAS DataBase Reference 6292-59-7(CAS DataBase Reference)
Hazard Codes Xi
Risk Statements 20/21/22
Safety Statements 22-36/37/39
Hazard Note Irritant
HS Code 29350090
4-tert-Butylbenzenesulfonamide is an intermediate as well as a degradation impurity of the endothelin receptor antagonist Bosentan.
Chemical Name 4-Tert-Butylbenzenesulfonamide
Synonyms
4-Tert-butylbenzenesulfonamide;
CAS No. 6292-59-7
Molecular Formula C10H15NO2S
Molecular Weight 213.29700
PSA 68.54000
LogP 3.41260
Appearance & Physical State white solid
Density 1.152 g/cm3
Boiling Point 337.2ºCat 760 mmHg
Melting Point 136-138ºC
Flash Point 157.7ºC
Refractive Index 1.536
Safety Statements 22-36/37/39
HS Code 2935009090
RIDADR UN3335
Risk Statements R20/21/22
Hazard Codes Xi
SAFETY DATA SHEETS
According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition
Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.
Identification
1.1
GHS Product identifier
Product name 4-Tert-Butylbenzenesulfonamide
1.2
Other means of identification
Product number -
Other names 4-Tert-butylbenzenesulfonamide
1.3
Recommended use of the chemical and restrictions on use
Identified uses For industry use only.
Uses advised against no data available
1.4
Supplier's details
Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166
1.5
Emergency phone number
Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).
2.
Hazard identification
2.1
Classification of the substance or mixture
Not classified.

2.2
GHS label elements, including precautionary statements
Pictogram(s) No symbol.
Signal word
No signal word.

Hazard statement(s)
none

Precautionary statement(s)
Prevention
none

Response
none

Storage
none

Disposal
none

2.3
Other hazards which do not result in classification
none

3.
Composition/information on ingredients
3.1
Substances
Chemical name Common names and synonyms CAS number EC number Concentration
4-Tert-Butylbenzenesulfonamide 4-Tert-Butylbenzenesulfonamide 6292-59-7 none 100%
4.
First-aid measures
4.1
Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact
Wash off with soap and plenty of water. Consult a physician.

In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2
Most important symptoms/effects, acute and delayed
no data available

4.3
Indication of immediate medical attention and special treatment needed, if necessary
no data available

5.
Fire-fighting measures
5.1
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2
Specific hazards arising from the chemical
no data available

5.3
Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.

6.
Accidental release measures
6.1
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3
Methods and materials for containment and cleaning up
Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.
Handling and storage
7.1
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

8.
Exposure controls/personal protection
8.1
Control parameters
Occupational Exposure limit values
no data available

Biological limit values
no data available

8.2
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3
Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection
Wear dust mask when handling large quantities.

Thermal hazards
no data available

9.
Physical and chemical properties
Physical state white solid
Colour no data available
Odour no data available
Melting point/ freezing point 253®C(lit.)
Boiling point or initial boiling point and boiling range 134®C/4mmHg(lit.)
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point 15®C(lit.)
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility no data available
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure no data available
Density and/or relative density 1.152 g/cm3
Relative vapour density no data available
Particle characteristics no data available
10.
Stability and reactivity
10.1
Reactivity
no data available

10.2
Chemical stability
Stable under recommended storage conditions.

10.3
Possibility of hazardous reactions
no data available

10.4
Conditions to avoid
no data available

10.5
Incompatible materials
no data available

10.6
Hazardous decomposition products
no data available

11.
Toxicological information
Acute toxicity
Oral: no data available
Inhalation: no data available
Dermal: no data available
Skin corrosion/irritation
no data available

Serious eye damage/irritation
no data available

Respiratory or skin sensitization
no data available

Germ cell mutagenicity
no data available

Carcinogenicity
no data available

Reproductive toxicity
no data available

STOT-single exposure
no data available

STOT-repeated exposure
no data available

Aspiration hazard
no data available

12.
Ecological information
12.1
Toxicity
Toxicity to fish: no data available
Toxicity to daphnia and other aquatic invertebrates: no data available
Toxicity to algae: no data available
Toxicity to microorganisms: no data available
12.2
Persistence and degradability
no data available

12.3
Bioaccumulative potential
no data available

12.4
Mobility in soil
no data available

12.5
Other adverse effects
no data available

13.
Disposal considerations
13.1
Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.
Transport information
14.1
UN Number
ADR/RID: UN3259 IMDG: UN3259 IATA: UN3259
14.2
UN Proper Shipping Name
ADR/RID: AMINES, SOLID, CORROSIVE, N.O.S. or POLYAMINES, SOLID, CORROSIVE, N.O.S.
IMDG: AMINES, SOLID, CORROSIVE, N.O.S. or POLYAMINES, SOLID, CORROSIVE, N.O.S.
IATA: AMINES, SOLID, CORROSIVE, N.O.S. or POLYAMINES, SOLID, CORROSIVE, N.O.S.
14.3
Transport hazard class(es)
ADR/RID: 8 IMDG: 8 IATA: 8
14.4
Packing group, if applicable
ADR/RID: III IMDG: III IATA: III
14.5
Environmental hazards
ADR/RID: no IMDG: no IATA: no
14.6
Special precautions for user
no data available

14.7
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available

15.
Regulatory information
15.1
Safety, health and environmental regulations specific for the product in question
Chemical name Common names and synonyms CAS number EC number
4-Tert-Butylbenzenesulfonamide 4-Tert-Butylbenzenesulfonamide 6292-59-7 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Not Listed.
EC Inventory Not Listed.
United States Toxic Substances Control Act (TSCA) Inventory Not Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Not Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Not Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Not Listed.
16.
Other information
Information on revision
Creation Date Aug 12, 2017
Revision Date Aug 12, 2017