25-hydroxyvitamin D3 Animal Feed Additive HD250

What is 25-hydroxyvitamin D3?
25-hydroxyvitamin D3(25-OH-D3), also know as 25-hydroxycholecalciferol, it is the metabolic product of the liver hydroxylation of vitamin D3. It is the main active form of vitamin D in human and animal blood circulation, and it is an indicator of the nutritional status of vitamin D3 in the body.
Molecular Structure
CAS-NO:63283-36-3
Formula:C27H44O2.H2O
Molecular Weight:418.7
25-hydroxyvitamin D3 Features
Regulates the absorption of phosphorus and calcium
The Production Technology of Haodi 25-hydroxyvitamin D3
25-hydroxy-7-dehydrocholesterol

Special light rearrangement equipment
Ring Opening
25-hydroxyvitamin D3
Microencapsulation
Haodi HD12500
Comparison of 25-hydroxyvitamin D3 and regular vitamin D3
25-hydroxyvitamin D3 Regular vitamin D3
Absorption Pattern Added a hydroxyl group, enhanced water solubility, independent of the micelle structure formed by bile secretion and fat absorption The mode of absorption of fat-soluble vitamins depends on the micellar structure formed by bile secretion and fat absorption
Absorption Speed Fast absorption - bypasses liver conversion and shortens the metabolic process of vitamin D3 in the body A bit slow- has to be transformed by liver
Liver Influence Unaffected by the liver dysfunction and reduce the burden of liver Affected by liver’s health
Bioactivity Active metabolit,
potency is 3-5 times
final biological activity is 20-40 times Inactive
To be active need to convert into 25-hydroxyvitamin D3
Half life 20-22 days 25 days


HAODI 25-hydroxyvitamin D3 Function(Pig for instance)
1.Strong Bones
2.Reproductivity
3.Muscle Growth
4.Immunoregulation
Strong Bones Function
Helps on Bone
1.Promote the synthesis of calcium-binding protein by intestinal mucosal cells, increase the absorption of calcium and phosphorus by intestinal mucosal cells, increase blood calcium and phosphorus concentrations, and facilitate bone calcification.
2.Promote the re-absorption of calcium and phosphorus in the proximal convoluted tubule of the kidney, reduce the excretion of urinary calcium and phosphorus, increase the blood calcium level, and increase the bone density.
3.Directly acts on the mineral metabolism of bone, promotes the formation of bone matrix and osteoid mineralization, promotes the differentiation of mesenchymal cells into osteoclasts, dissolves bone salts, increases the concentration of blood calcium and phosphorus, which is beneficial to the calcification of new bones and promotes osteogenesis effect.
4.Regardless of whether the blood calcium level is normal or not, 25OHD3 and parathyroid hormone can interact, convert and excrete, so 5-10 times the dosage of 25OHD3 in pigs will not have adverse effects.
Helps On Reproduction
1.Improve the screening rate of gilts and prolong the service life of sows
2.Reduce manual intervention in the delivery process and reduce the occurrence of delivery complications
3.Improve the quality and quantity of boar semen, improve the conception rate and yield of sows
4.Increase piglet weaning litter weight

Helps On Muscle Growth
1, By increasing the number of fetal myofibroblasts, suckling pigs can obtain more muscle fibers after birth, which is beneficial to later muscle growth
2.Increases growth factors and genes that contribute to muscle production, promotes more differentiation of stem cells into myoblasts, and improves myotube formation.
3.Stimulate the muscle calcium level, increases the protease activity in muscle, and improves the water holding capacity of meat, thereby promoting the tenderization of meat and the improvement of meat color.

Helps On Immunity
1.Enhances the ability of monocytes to transform into macrophages and the phagocytic ability of macrophages such as the expression of beta defensin-beta2 in intestinal epithelial cells
2.Improve the number and vitality of immune cells, significantly increase the level of rotavirus antibodies in the serum and intestinal tract of weaned piglets, and effectively block the intestinal endotoxin (LPS) and the invasion of Escherichia coli to the intestinal tract.

HAODI 25-hydroxyvitamin D3 Recommended Dosage
Product Code 25-hydroxyvitamin D3mg/kg ≥ Pig(g/KG) Poultry(g/KG)
HD12500 12500 0.004 0.005-0.0055
HD10000 10000 0.005 0.0065-0.007
HD1250 1250 0.04 0.05-0.055
HD500 500 0.1 0.125-0.1375
HD250 250 0.2 0.25~0.275