Raw Steroid High Purity Powder 4-Androstenedione / 4-AD CAS 63-05-8 For Bodybuilding

Abstract

4-Androstenedione is the common precursor of male and female sex hormones. Some 4-Androstenedione is also secreted into the plasma, and may be converted in peripheral tissues to testosterone and estrogens.

4-Androstane-diones are a pair of isomeric steroids which differ at the 5-position. They are distinguished as 5α-androstane-dione and 5β-androstane-dione. In humans, 5α-androstane-dione is a metabolic precursor of both testos-terone and estrone.


Simplified hormone drugs, from the testis or urine extracted with the role of a male hormone steroids, norethisterone, testosterone propionate in the middle Body, is widely used in small rheumatoid arthritis, diuretic, and a variety of contraceptive to control infectious inflammation.

4-Androstenedione can be synthesized in one of two ways.

The primary pathway involves conversion of 17-hydroxypregnenolone to dehydroepiandrosterone by way of 17,20-lyase, with subsequent conversion of dehydroepiandrosterone to 4-Androstenedione via the enzyme 3-β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to 4-androstenedione directly by way of 17,20-lyase. Thus, 17,20-lyase is required for the synthesis of 4-androstenedione, whether immediately or one step removed.

The production of adrenal 4-Androstenedione is governed by ACTH, whereas production of gonadal 4-Androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and ovaries each produce about half of the total 4-androstenedione(about 3 mg/day). After menopause, 4-androstenedione production is about halved, due primarily to the reduction of the steroid secreted by the ovary. Nevertheless, 4-androstenedione is the principal steroid produced by the postmenopausal ovary.


Usage


4-Androstenedione is further converted to either testosterone or estrogen.

In males,
conversion of androstenedione to testosterone requires the enzyme 17β-hydroxysteroid dehydrogenase.

In females,
androstenedione is released into the blood by theca cells. Conversion of androstenedione to estrogen (e.g., estrone and estradiol) requires the enzyme aromatase. Androstenedione is a substrate for estrogen production in granulosa cells which produce aromatase. Thus, theca cells and granulosa cells work together to form estrogens.

Used for simplified hormone drugs, from the testis or urine extracted with the role of a male hormone steroid, norethisterone, testosterone propionate in the middle body, is widely used in small rheumatoid arthritis, diuretic, and a variety of contraceptive to control infectious inflammation.